Vatican City & Prati Area
Even if it looks like another part of Rome, Vatican City is the smallest internationally recognized independent state in the world by both area and population. The Vatican Museums, St. Peter's, and the Vatican Gardens take up most of the land area, and the popes have lived here for 6 centuries. The neighborhood north of the Vatican—called "Borgo Pio"- is a nice alternative to walk around, with plenty of bars and restaurants, some of them very touristy. The white-collar Prati district, a middle-class suburb just east of the Vatican, is possibly a better choice if you want to walk around a more "modern" area with its shopping streets, and the fact that it boasts some excellent places to eat.
Spot where religion and history takes place
You don't have to be Catholic to be moved by the beauty, structural integrity, or domineering display of passion present in Vatican City and Borgo. You don't have to be religious to appreciate it, either. Every year, thousands of vistors arrive in San Pietro square, to admire the incredible San Pietro Basilica and line up for hours to see the breathtaking Sixtine Chapel and all the incredible art stored in this area.
What tourists love
The borghi brim with small shops, restaurants, and everyday residents going about their business in the shadow of the Vatican. Religious shops and commemorative souvenir stalls intersperse throughout sidewalk tables and modest apartments. Borgo represents a very nice and interesting meeting place for tourists and Romans because of the plenty of bars, pubs and restaurants that fill the narrow streets. Especially during the warm summer evenings, this area is joined by young people from all over the world